The newer sedative-hypnotics

Lucia Sukys-Claudino, Walter André dos Santos Moraes, Sergio Tufik, Dalva Poyares

there has been a search for more effective and safe hypnotic drugs in the last decades. Zolpidem, zaleplon, zopiclone, eszopiclone (the z-drugs) and indiplon are GABA-A modulators which bind selectively α1 subunits, thus, exhibiting similar mechanisms of action, although recent evidence suggests that eszopiclone is not as selective for α1 subunit as zolpidem is. Ramelteon and tasimelteon are new chrono-hypnotic agents, selective for melatonin MT1 and MT2 receptors. On the other hand, the consumption of sedative antidepressant drugs is significantly increasing for the treatment of insomnia, in the last years. As an experimental drug, eplivanserin is being tested as a potent antagonist of serotonin 2-A receptors (ASTAR) with a potential use in sleep maintenance difficulty. Another recent pharmacological agent for insomnia is almorexant, which new mechanism of action involves antagonism of hypocretinergic system, thus inducing sleep. Finally we also discuss the potential role of other gabaergic drugs for insomnia

Pro Vida

Pro Vida

es un  programa  integral,  diseñado  para proveer  diversos  beneficios a pacientes  crónicos. Descuentos  desde su  primera compra, alianzas  con Laboratorios  y  Centro  de Diagnóstico y charlas educacionales al paciente crónico.

Si su médico le ha recetado alguna de las marcas que incluye el programa y  desea obtener todos los beneficios que Provida le ofrece, favor comunicarse al Call Center, para afiliarse y ser parte del programa.

Productos destacados

It seems we can't find what you're looking for.