Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host−Virus Interaction, and Proposed Neurotropic Mechanisms

Abdul Mannan Baig,* Areeba Khaleeq, Usman Ali, and Hira Syeda

The recent outbreak of coronavirus infectious disease 2019 (COVID19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect humans worldwide. As we are in the midst of an ongoing pandemic of COVID-19, scientists are struggling to understand how it resembles and differs from the severe acute respiratory syndrome coronavirus (SARSCoV) at the genomic and transcriptomic level. In a short time following the outbreak, it has been shown that, similar to SARS-CoV, COVID-19 virus exploits the angiotensinconverting enzyme 2 (ACE2) receptor to gain entry inside the cells.

This finding raises the curiosity of investigating the expression of ACE2 in neurological tissue and determining the possible contribution of neurological tissue damage to the morbidity and mortality caused by COVID-19. Here, we investigate the density of the expression levels of ACE2 in the CNS, the host−virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak. Also, we debate the need for a model for staging COVID-19 based on neurological tissue involvement.

Pro Vida

Pro Vida

es un  programa  integral,  diseñado  para proveer  diversos  beneficios a pacientes  crónicos. Descuentos  desde su  primera compra, alianzas  con Laboratorios  y  Centro  de Diagnóstico y charlas educacionales al paciente crónico.

Si su médico le ha recetado alguna de las marcas que incluye el programa y  desea obtener todos los beneficios que Provida le ofrece, favor comunicarse al Call Center, para afiliarse y ser parte del programa.

Productos destacados

It seems we can't find what you're looking for.